You are probably reading this article because you’ve recently heard about nitric oxide supplements.

Are you looking for a natural supplement that may help build more muscle, but also improve your recovery time after a workout? Do you want to streamline your body’s ability to function more efficiently on a cellular level? Perhaps you want to lower your blood pressure, improve your immune function, or protect your brain and heart health.

If so, you may wonder what you can do…

Adding a top nitric oxide supplement to your daily routine may be the answer.

Nitric oxide (NO) pills are inexpensive, at around $11 to $27, and simple way to help boost the effectiveness of your workouts so you are not wasting any precious time training hard and not getting the results you are seeking.

There is nothing worse than eating the right way and training hard, only to see painfully slow growth or lackluster results that leave you feeling defeated and frustrated.

The other effects of increased NO in the body are added benefits for overall health as well.

In this article and review, we will look at:

  • What NO supplements are
  • How they work
  • The benefits of nitric oxide supplements
  • The side effects of nitric oxide supplements
  • How you should use the supplements correctly

We will also discuss the top nitric oxide supplements available, so you can achieve your best body and feel the healthiest you have in years.

What is NO?

Nitric oxide is a gas produced by your body naturally and plays a role in just about every cell function. Nitric oxide helps your cells communicate with each other. NO also controls proper blood circulation and regulates how your organs, such as your brain, lungs, and stomach work.

When you exercise or strength train, your muscles need more oxygen. The blood supplies this oxygen and as your heart pumps harder, your arteries release the nitric oxide, which widens the vessel wall, allowing more blood through. Nitric oxide is also embedded in your sinuses. You’ve often heard to breathe in through the nose and out through the mouth? This is because inhaling through the nose stimulates NO and it follows the airstream to your lungs and lower airways. This gives you more of a cardiovascular boost.

What are the benefits of Nitric Oxide?

Taking Nitric Oxide SupplementsNO is a popular way to control high blood pressure and help maintain a properly functioning cardiovascular system.

Essentially, NO produced by the body is generated in the vasculature and then spreads to the muscle underneath causing the muscles in that area to relax. As a result, blood pressure drops and an increase in blood flow and oxygen move to the area. This means you have a boost to power and endurance.

It’s also why during periods of extreme activity you want to make sure you’re breathing in deeply through the nose and not through your mouth. Breathing through the mouth doesn’t allow for the dispersion of NO like breathing through the nose does. Mouth breathing may also spike your stress hormones which can have a negative impact on your performance.

NO plays an important part in brain function as well. NO can help a variety of neurological processes as both underproduction and overproduction can have major effects on memory and diseases like Parkinson’s, Alzheimer’s, and conditions like depression. Patients who have less NO production in the body than average receive less blood flow to their brain, which can increase inflammation and stress in the brain.

Nitric oxide can also improve your immune system since certain cells in the body generate nitric oxide and help your body defend itself against a wide variety of pathogens and bacteria. For instance, it controls infectious diseases, tumors, and chronic degenerative diseases such as kidney disease due to its reaction partners.

Although there are much less evidence and research on NO and how they affect and improve workout performance, muscle growth, and recovery time, we are seeing more information popping up in studies that claim nitric oxide supplements benefits this as well.

A study suggests nitric oxide supplements can increase stamina and workouts last 20% longer

One study conducted by the University of Exeter found that supplements that boost the production of NO in the body have a significant impact on stamina during high-intensity workouts. In fact, the study found it helped athletes workout 20% longer, and it decreased their race times by 1-2%.

Overall, they have proven nitric oxide helps in the following areas and shows the many reasons why you should consider taking a nitric oxide supplement:

  • Lowers blood pressure and helps maintain a healthy cardiovascular system.
  • It improves brain function.
  • Improves the immune system.
  • Improves workout performance and stamina during workouts.


If you want to add a nitric oxide supplement into your daily routine, it is as simple as finding your preferred supplement and taking the pill with food in the morning. Viola, you will begin to reap its benefits!

How do nitric oxide supplements work?

Wondering How Nitric Oxide Supplement WorksYou may now wonder:

How do these little pills actually work?

Nitric oxide supplements do not actually contain nitric oxide…What?

Rather, they contain amino acids that convert to NO in your body. The best nitric oxide supplements contain arginine or L-arginine. Taking this dietary supplement gives your body a push to produce more nitric oxide than it normally does in the endothelial cells.

Once your body can produce more NO than normal, your blood flow will increase and it carries more oxygen to the muscles that are working during your workout.

Therefore, nitric oxide supplements are believed to help you work out for an extended period and help speed up muscle recovery after your workout. It is important to note that although there are some studies that show NO supplements improve a workout, there are also studies that found NO has little effect on workout stamina. Conflicting information like this is typical in areas in the scientific community that have not been abundantly researched.

Some claim this process fills your muscles with blood, which helps make your muscles look more pronounced. However, there is still debate in the scientific community whether this is actually what happens.

Types of nitric oxide supplements

Although there are varying forms of nitric oxide pills, they all contain one or more forms of arginine. As we discussed above, this ingredient is a precursor for the production of nitric oxide in the body.

L-arginine, L-citrulline, citrulline malate, nitrate, and flavonoids are common ingredients found in the top nitric oxide supplements to help boost the production of NO in the body.

Side effects of nitric oxide supplements

Side Effects of Nitric Oxide SupplementsAs with any supplement, there are side effects you should know before you start a new supplement regimen.

Changes in blood pressure are one of the most common side effects. Decreased blood pressure is common since the supplement affects your blood vessels. Symptoms of low blood pressure include lightheadedness, nausea, vomiting, and headaches. If you suffer from blood pressure issues, speak with your doctor before you begin a NO supplement regimen.

Stomach issues like stomach aches, cramps, increased number of stools, and bloating happen as well. You might be able to counteract some of these side effects if you take the supplements with meals. Again, speak to your physician to get advice and learn the appropriate way to take supplements based on your personal health background.

Electrolytes may change with the use of a NO supplement as well. NO can change the chemical environment of your body, especially if you have kidney or liver disease. NO can create high potassium, chloride, urea nitrogen, creatinine, and low sodium and phosphate levels, which can drastically affect electrolyte levels.

Nitric oxide supplements may increase bleeding as well.

Common side effects from nitric oxide supplements:

  • Changes in blood pressure.
  • Stomach issues – bloating, cramps, pain, nausea, vomiting.
  • Changes in electrolyte levels.
  • Increased bleeding.

How to take nitric oxide supplements

Depending on how you plan you use nitric oxide and what use you are using it for (to lower blood pressure, increase immune function, etc.) or to use it is a muscle or workout enhancers, the dosage and recommended supplementation will vary. It will also vary depending on your age, gender, and body weight.

To find the proper dosage for your needs and your body, your best bet is to speak with your trusted healthcare professional to determine a safe level of nitric oxide supplementation.

Want to know what the best nitric oxide supplements are?

Take a peek at our list below:

The Top 5 Nitric Oxide Supplements

Havasu Nutrition – L-Arginine Extra Strength

Havasu Nutrition L-Arginine Extra StrengthAs far as the best nitric oxide supplements go, Havasu Nutrition’s L-arginine supplement is the most popular option for those looking for a powerful NO supplement for muscle growth, vascularity, and boosting energy. Havasu is known for its high-quality products with an intense purity testing process, no preservatives, chemicals, or artificial sugars/ingredients in their supplements.


  • Superior extra strength L-arginine with both arginine HCI and arginine Alpha-ketoglutarate, plus L-citrulline that provides the ultimate synergistic blend available.
  • No preservatives, chemicals, artificial ingredients, or artificial sugars.
  • Third-party product testing and available purity documentation.
  • Will never give you the jitters.
  • Free of gluten, corn, wheat, rice, barley, and oats.
  • Affordable for the quality of the product
  • Made in the USA.

Who Makes It

Havasu Nutrition is a trusted company that provides innovative natural solutions and supplements that aim to provide users with some of the best quality and purest supplements on the market. They pride themselves on their transparency and provide third-party testing results on their website, so you can ensure that you are getting high-quality supplements. They manufacture all products in the USA, GMP certified, and they have a 100% money-back guarantee.

The Bottom Line

 In an industry known for low-quality and tainted products, the quality and peace of mind that Havasu Nutrition provides goes almost unmatched. With no chemicals, preservatives, artificial ingredients, or fillers, you are getting clean, pure L-arginine that can deliver the results you desire. They make all of their products in the USA, go through rigid third-party testing, and are produced in an FDA-approved facility. Coupled with their praising reviews, you can trust the quality and effectiveness of this NO supplement.

NOW – L-Arginine 1000 mg Tablets

NOW – L-Arginine 1000 mg Tablets NOW provides a double strength L-arginine tablet that is non-GMO, premium grade, and GMP certified. The pills are smaller and easy to swallow. NOW uses high-quality ingredients with no chemical fillers that can harm your body. Although people use this product for endurance during a workout, it is not particularly formulated with muscle growth and workout performance in mind and more geared towards people suffering from erectile dysfunction, high blood pressure, or those looking for improved brain function and immune system health.


  • Manufactured in the USA.
  • All the ingredients are non-GMO.
  • Double strength and premium grade L-arginine.
  • Produced in a GMP certified facility.
  • One of the most affordable brands of L-arginine on the market.

Who Makes It

NOW Foods is one of the oldest and most trusted supplement and natural products companies in the world. They have been in operation since 1968 and are a family-owned and operated company. All of their products are sustainably produced, and the company has a strict charitable commitment policy that allows them to give to those in need when they see fit. Many of their products are bestsellers, including their L-arginine supplements.

The Bottom Line

Overall, if you are looking for a pure, high-quality, and non-GMO L-arginine supplement that is not specifically geared towards workout performance and muscle gain, and rather for other health issues and concerns, this will be your best option. Its double-strength formula has helped thousands of users improve circulation, blood pressure, and erectile dysfunction in a natural, easy way. Additionally, these are one of the most affordable options on the market, making it much easier to financially maintain your supplement regimen. With its top-rated position on Amazon plus other benefits, you cannot go wrong with this option.

NOW Sports – L-citrulline 1200 mg Tablets

NOW Sports – L-citrulline 1200 mg TabletsThe same brand as the above product, NOW Sports is geared towards those looking for increased performance on the field or in the gym. All quality, testing, and values are the same in the Sports line as their regular option line of supplements. However, this product’s main ingredient in L-citrulline, another compound that converts to nitric oxide in the body. These supplements are an extra strength option, are wonderful for maintaining a healthy immune system, but many people use them for stamina during a workout and maintaining endurance for a longer period of time. People also claim the product works well for less muscle soreness after an intense workout. There are no chemical fillers or preservatives in the supplements.


  • Manufactured in the USA.
  • No chemical ingredients.
  • Extra strength formula.
  • Often used for workout stamina, endurance, and for feeling less sore after an intense workout.
  • Top-rated Amazon product
  • Great for supporting a healthy immune system, lowering blood pressure, and treating erectile dysfunction as well.

 Who Makes It

Although the brand is NOW Sports, it is made by NOW Foods, the same company we discussed in the review above. All of the company practices apply to this product as well.

The Bottom Line

NOW Sports is a wonderful and reliable company that has been in business for over 50 years. We can trust their products for purity and quality, and that goes for these nitric oxide boosting supplements as well. If you are an athlete or serious about your workout, looking to increase endurance and muscle, and want to achieve faster recovery, trying these L-citrulline supplements may just be the best way to achieve your goals. However, they can also be effectively used for other health conditions, such as high blood pressure. 

Sheer Strength Labs – Sheer N.O.

Sheer Strength Labs – Sheer N.O.Sheer N.O. is a product used for building muscle and strength. It aims to increase blood flow, workout performance, and stamina in the gym for ultimate workout and recovery effectiveness. The supplements are extra strength to provide fast results; they support NO production in the body easily, are non-habit forming, non-addictive, are free of gluten, Non-GMO, and made in the USA. They use a special formula in their supplements that include 2,200 mg of L-arginine, 600 mg of citrulline, and pine bark extract that is a natural nitric oxide booster and also aids in mental performance. Mental focus, mood, and mental clarity improve as well. There are two types of L-arginine to truly give your workouts and muscles a boost – 1100 mg of HC Plus and 1100 mg of AKG.


  • Made in the USA
  • Gluten-free and non-GMO.
  • 30-day 100% money-back guarantee if it does not satisfy you.
  • Two types of L-arginine for ultimate performance and muscle growth.
  • Pine bark extract for improved mental performance.

Who Makes It

This product is made by Sheer Strength Labs and they consider themselves one of the fastest growing sports nutrition companies in the USA. They make a wide variety of weight loss and workout-based supplements, many of those are nitric oxide boosting supplements. Although many of their products are highly rated and receive great reviews from happy users, they do not appear to have much information about the company on their website. We do not know if they test their products for purity, if they use a third-party testing lab or are GMP certified. It would be beneficial to have access to this information readily, as it is important information to most consumers.

The Bottom Line

Sheer N.O. is a great product that is trusted by many and used with wonderful results in most cases. They provide a 30-day 100% money-back guarantee, which gives you some peace of mind if you want to try their products but are not sure if you will like the supplements. The added natural pine bark extract for improved mental performance is an added benefit for many users. However, if you are looking for a product with testing results, more reviews, and more transparency about their supplements, you may be better off with a different nitric oxide supplement.

Six Star Explosion Pre-Workout

Six Star Explosion Pre-WorkoutSix Star Explosion is a bit different from the other supplements on our list because it is a pre-workout drink that includes a few forms of L-arginine and L-citrulline along with other nutritional supplements like caffeine and green coffee extract. Green coffee extract is a more natural caffeine source and also gives you antioxidants. It also acts as a weight loss drink, which comes from the green coffee extract. Beta-alanine, choline, and L-tyrosine provide explosive energy and improved mental focus during your workout. The company third-party tests their formulas for quality and purity and all the products are made in the USA. This brand also makes MuscleTech, which is the number 1 best-selling bodybuilding brand in America, so you can feel extra confident you are getting a product that will give you the result you want.


  • Made in the USA.
  • Third-party tested for quality and purity.
  • From the makers of the number 1 best-selling bodybuilding product line in America.
  • Combines the best forms of L-arginine with other effective ingredients for the best workout experience possible.
  • Aids in weight loss.
  • One of the most affordable pre-workouts on the market with L-arginine.

Who Makes It

This product is made by the makers of MuscleTech, the best-selling bodybuilding brand in the US, Six Star. The company engineers their products for athletes and hardcore trainers looking to build lots of muscle, have lots of endurance and get in the most effective workout possible. They test their products with a third-party lab to ensure their product is the best quality it can be.

The Bottom Line

 Six Star is a great product if you are looking to build muscle fast and maintain an intense workout schedule consistently. The L-arginine paired with the other muscle building and repairing ingredients will boost your nitric oxide levels. Those simply looking to improve blood pressure or other health concerns like boosting the immune system should not use this product. This product is for building muscle quickly. If you are looking for a pure form of L-arginine with no other ingredients you may deem unnecessary, this is not the product for you.

The Bottom Line for Using Nitric Oxide Supplements

A high-quality nitric oxide supplement from a reputable company may be a great addition to your daily health care routine.

Whether you are seeking to use nitric oxide for lowering blood pressure, helping boost the immune system, building muscle and improving workout endurance, or another reason, giving one of the above supplements a try may have a significant positive impact on your health.

Finding a natural and healthy way to help improve any of the above concerns or conditions is a fantastic way to take control of your health and your body.

You must evaluate the benefits, drawbacks, and side effects of taking nitric oxide supplements in order to determine if beginning a nitric oxide regimen is right for you. Speaking with your healthcare professional before starting a new supplement is essential as well.

Whatever your reason is for taking nitric oxide, choosing the right supplement, sticking to your new routine, and feeling the amazing benefits of the best nitric oxide supplement for your body will have you feeling your best and strongest ASAP.

Do you think nitric oxide supplements really work?

  1. Mostly, definitely…I’m convinced!
  2. I am interested but skeptical.
  3. No way…seems like just another health trend.